Dissociation of the positive inotropic action of digitalis from inhibition of sodium- and potassium-activated adenosine triphosphate.
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چکیده
ARD TUTTLE 29 Antagonism of Peripheral and Central Effects of Angiotensin II by [1-Sarcosine, 8-IsoleucinejAngiotensin II. C. S. SWEET, C. M. FERRARIO, M. C. KHOSLA AND F. M. BUMPUS 35 Adrenal and Striatal Tyrosine Hydroxylase Activity after Methamphetamine. LEONARD Y. KODA AND JAMES W. GIBB 42 Electrophysiological Properties of Splenic Nerve in Relation to Norepinephrine Overflow. C. Y. K.to AND J. R. MCCULLOUGH 49 Long-Lasting Supersensitivity of the Rat Vas Deferens to Norepinephrine after Chronic Guanethidine Administration. BARBARA EVANS, T. IWAYAMA AND G. BURNSTOCK 60 The Actions of 5-Hydroxytryptamine on the Urinary Bladder and on Vesicai Autonomic Ganglia in the Cat. WILLIAM R. SAUM AND WILLIAM C. Dli GROAT 70 Effects of Ascorbate on Contractile Activity of heal Smooth Muscle. PAUL D. JOINER 84 Determination of Serum d-Tubocurarine Concentration by Radioimmunoassay. PETER E. HoRo-
منابع مشابه
Effects of Ouabain
SUMNIARY XMyocardial electrolyte balance and hemodynamics were studied in 14 patients before and after the administration of ouabain. The drug caused a significant loss of potassium from the myocardium. This was accompanied by a significant positive inotropic response, indicated by an increase in the rate of rise of left ventricular pressure and systolic ejection-rate index. Heart rate, cardiac...
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SUMMARY Prior to consideration of the effects of digitalis compounds on ionic exchange the basic mechanisms of active Na+ and K+ transport are discussed. It is generally accepted that digitalis is a specific inhibitor of the Na+-K+ activated ATPase located primarily in the sarcolemmal membrane. Present evidence supports the concept that positive inotropic effects of digitalis are not seen unles...
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The effects of sodium pump inhibition produced by exposure to the cardiac glycosides, ouabain or dihydroouabain, or by reduction in extracellular potassium to 1.0 mM, on contractile state and sodium-calcium exchange were studied in primary monolayer cultures of chick embryo ventricular cells. Ouabain, 10(-6)M, dihydroouabain, 5 X 10(-5)M, and extracellular potassium of 1.0 mM all induced simila...
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Estimates of initial binding rates for [3H]ouabain interaction with (Na+ + K+)-ATPase were obtained in the presence of ATP, magnesium, sodium, and potassium by using short assay times at 30”. The reactions were terminated by the rapid addition of excess unlabeled ouabain; this did not appear to displace bound [3H]ouabain during subsequent treatment of the suspensions (prior to assay). Initial b...
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Growth of cultured cells in low potassium medium has been shown to result in an increase in the number of Na,K-ATPase sites. This phenomenon and its physiological and pharmacological consequences were examined in spontaneously beating monolayers of cultured chick heart cells. Growth of cells in 1 mM extracellular potassium, 2 ^M ouabain, or 1 /*M veratridine for 48 hours caused 60%, 40%, or 20%...
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ورودعنوان ژورنال:
- The Journal of pharmacology and experimental therapeutics
دوره 185 1 شماره
صفحات -
تاریخ انتشار 1973